WCCRM has been reviewing nutrients that have suggested better outcomes with colds, flus and viral infections. Key ingredients have been selected in light of this pandemic to provide nutrients to support a healthy immune system and lower inflammatory status in the body.
The ingredients of this kit have been selected based on the recovery of patients that have been managed by telemedicine by WCCRM. Patients in this recovery group ranged in age from 40-84 years of age with comobidities like diabetes, obesity, and cardiovasuclar disease. Recoveries times varied between 10-40. No cases required hospitalization.
Contains synergistic ingredients that support a healthy immune system in the gut, prevent colds and flus, treat upper respiratory tract infections, anti-oxidants and bioflavonoids which synergistically work with vitamin C, accelerate recovery from viral infections, reduce swelling in mucous membranes, inhibit viral replication, increases resistance to viral infections, have mechanisms of action similar to hydroxychloroquine without the side-effects.
"NAC exhibits a mucolytic effect due to its free sulfhydryl group which reduces disulfide bonds in the cross-linked mucus glycoproteins matrix, thereby lowering mucus viscosity; and NAC is a potent antioxidant with a direct effect on certain oxidant species, an indirect effect because it acts as a precursor to cysteine (required for glutathione synthesis), and the ability to restore thiol pools which in turn regulate redox state"
N-acetylcysteine as a potential treatment for novel coronavirus disease 2019. Future Microbiol. 2020 Jun : 10.2217/fmb-2020-0074.
High-dose N-acetylcysteine therapy for novel H1N1 influenza pneumonia.
Ann Intern Med. 2010 May 18;152(10):687-8.
"Vitamin A (VitA) is a micronutrient that is crucial for maintaining vision, promoting growth and development, and protecting epithelium and mucus integrity in the body. VitA is known as an anti-inflammation vitamin because of its critical role in enhancing immune function. VitA is involved in the development of the immune system and plays regulatory roles in cellular immune responses and humoral immune processes. VitA has demonstrated a therapeutic effect in the treatment of various infectious diseases."
"using immunomodulatory agents such as melatonin as an effective adjuvant besides vaccination may boost the vaccine's effectiveness in patients with both compromised and healthy immune systems. As above-mentioned, melatonin is capable of enhancing the count of natural killer and CD4+ cells and amplifying the production of cytokines needed for effective vaccine response"
"randomised controlled trials conducted from 2007–20 reveal protective effects of vitamin D against acute respiratory infections, albeit these effects were of modest size and with substantial heterogeneity.1 The striking overlap between risk factors for severe COVID-19 and vitamin D deficiency, including obesity, older age, and Black or Asian ethnic origin, has led some researchers to hypothesise that vitamin D supplementation could hold promise as a preventive or therapeutic agent for COVID-19.
From a mechanistic angle, there are good reasons to postulate that vitamin D favourably modulates host responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), both in the early viraemic and later hyperinflammatory phases of COVID-19."
"Nutritional supplements of curcumin with vitamin C and zinc have showed promising results in boosting the natural immunity and protective defense against the CoV infections have been noted in many hospitalized patients in Indian setting. It is also noted that pharmacological formulation of curcumin in nanoemulsion system proved increased solubility and bioavailability and with enhanced antihypertensive effect "
""Most COVID-19 patients develop pneumonia accompanied with respiratory tract symptoms, including cough, sore throat, sputum production, hemoptysis, nasal congestion, dyspnea and shortness of breath (Escalera-Antezana et al., 2020; Guan et al., 2020; Wang et al., 2020a; Young et al., 2020; Zhang et al., 2020). COVID-19 patients admitted to intensive care unit have more severe respiratory symptoms. Among 1300 patients with available respiratory support data, 1287 (99%) require respiratory support, and a large part of patients need positive end-expiratory pressure. But there is still a high mortality rate of 26% in intensive care unit (Grasselli et al., 2020). The pathological features of COVID-19 show bilateral diﬀuse alveolar injury with cellular fbromyxoid exudates. Right lung sample displays obvious desquamation of pneumocytes and hyaline membrane formation, indicating ARDS, whereas, the left shows pulmonary oedema with hyaline membrane formation. And the bilateral lung tissue exhibits obvious inflammatory infiltration in COVID-19 patients (Grasselli et al., 2020). The elderly and people with underlying diseases are susceptible to infection and prone to serious outcomes even death, which may be associated with ARDS. ARDS can induce inflammatory response and cytokine storm following heavily release of proinflammatory cytokines IFN-γ, TNF-α, interleukin and chemokines, which increase organ damage and accelerate the deterioration of the disease status (Guo et al., 2020; Mehta et al., 2020). Magnesium sulfate as a calcium antagonist is commonly used to inhibit bronchial smooth muscle contraction and promote bronchodilation (Hirota et al., 1999; Landon and Young, 1993; Torres et al., 2012). It also decreases inflammatory response and oxidative stress, as well as improves lung inflammation possibly by inhibiting IL-6 pathway, NF-κB pathway, and L-type calcium channels (Güzel et al., 2019; Kao et al., 2011). Therefore, magnesium sulfate has a good application prospect in controlling pulmonary symptoms."
"Rationale for Using Vitamin C in Patients With COVID-19
Vitamin C (ascorbic acid) is a water-soluble vitamin that is thought to have beneficial effects in patients with severe and critical illnesses. It is an antioxidant and free radical scavenger that has anti-inflammatory properties, influences cellular immunity and vascular integrity, and serves as a cofactor in the generation of endogenous catecholamines.1,2 Because humans may require more vitamin C in states of oxidative stress, vitamin C supplementation has been evaluated in numerous disease states, including serious infections and sepsis. Because serious COVID-19 may cause sepsis and acute respiratory distress syndrome (ARDS), the potential role of high doses of vitamin C in ameliorating inflammation and vascular injury in patients with COVID-19 is being studied."
"antioxidant compounds, prominently flavonoids, exhibit antiviral action in models of coronavirus infections. In general, the antiviral activity might be attributed, at least in part, to the inhibitory effect on the enzymatic activity of targets involved in coronavirus replication"